The disorder can occur at any age, but most often affects people between 40 and 60 years of age. Environmental, infectious and some genetic factors may play a role in the development of the disorder, including cigarette smoking. Autoimmune disorders occur when the body’s immune system mistakenly attacks healthy tissue. It is classified as an autoimmune disorder. Granulomatosis with polyangiitis is not an inherited disorder. Other symptoms can occur depending on which organ systems are affected in an individual. If the lungs are affected, a cough, coughing up of blood (hemoptysis), and inflammation of the thin membrane lining the outside of the lungs and the tissues inside of the lung may be present. In some individuals, kidney abnormalities may progress to kidney failure, a serious complication that requires dialysis or a kidney transplant. Symptoms may include ulcerations of the mucous membranes in the nose with secondary bacterial infection, a persistent runny nose, sinus pain, and chronic middle ear infection (otitis media) potentially resulting in hearing loss. Granulomatosis with polyangiitis (GPA) is a rare disorder characterized by inflammation of small- and medium-sized blood vessels (vasculitis) that results in damage to various organ systems of the body, most often the respiratory tract and kidneys. 5 Myths About Orphan Drugs and the Orphan Drug Act.Information on Clinical Trials and Research Studies.

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